About Parkinson's Disease

Parkinson's disease (named after the doctor who documented the "shaking palsy" in 1817) is a progressive disorder that affects nerve cells (neurons) in the part of the brain that controls muscle movement. This group of nerve cells (substantia nigra) makes dopamine, a chemical which is important for transmitting signals from one group of brain cells to another to facilitate movement. As dopamine-producing cells are lost, walking, arm movements and facial expressions are affected. By the time Parkinson's disease symptoms appear, 50 to 80 percent or more of these cells have been lost.Parkinson's disease evolves as the concentration of dopamine in the substantia nigra decreases. The parkinsonian symptoms are not evident until the concentration of dopamine starts to go below 20 per cent of the normal. As part of the decrease in dopamine concentration, the post-synaptic receptors within the caudate nucleus and the putamen develop hypersensitivity. So in Parkinson's disease, the dopamine receptors are hypersensitive simply because the concentration of dopamine has decreased. The basal ganglia control movement by two balance systems, one cholenergic and other dopangeric in which the chemical transmitter is dopamine. In Parkinsonism the dopanergic system is defective and the cholenergic system is dominant. Than the features of PD become visible. These features are defined by, tremor, rigidity and hypokinesia.
 
Causes For Parkinsons Disease : 

Childhood: In case of any health problems encountered during early childhood, most common causative agents and causative cofactors are: birth trauma, exposure to medications,  vaccination, toxins, child was fed with artificial milk, intolerance or allergy to mother's milk, toxic environment, toxins present in air or food and water that mother is consuming.Health problems encountered later in life: most common cofactors and causative agents affecting health of a modern man are: medications, birth trauma, vaccination, toxins, stress & unpleasant life experiences, poor mental health, poor attitude, poor lifestyle, poor diet, exposure to certain viruses, bacteria, yeast, parasitic animals.
That doesn't mean that every single person is exposed to the same causative agents.

Different people can be diagnosed with the same illness, but still have the entirely different set of cofactors causing that same illness.  Every person is different!  Every individual lives different life!

Other Reasons For Cause Of Parkinsons can be Wrong mental attitude, stress, suppression, negative thoughts, fear, lack of love, lack joy, lack desire to live, Lack of: physical activity, sweating, moving, too much of sex, lack of self control in life & Enjoying too much Of Sensual Pleasures Of Life...

Diagnosis Of Parkinsons

No specific test can diagnose Parkinson's disease. Diagnosis is usually made based on the patient's history and a comprehensive neurologic examination. Similar symptoms can be caused by certain medications and by other degenerative brain conditions.

Getting an accurate diagnosis is key to starting appropriate treatment that may help manage symptoms for years.
 
People with idiopathic Parkinson's disease may develop several symptoms over
time, but they typically develop the primary symptoms bradykinesia, tremor, rigidity, and parkinsonian gait. Most people with Parkinson's do not develop all of the symptoms associated with the disease.

Symptoms Of Parkinsons Disease

Symptoms may vary from day to day or even moment to moment. There is no clear reason for the fluctuation of symptoms. Variance may be attributable to the disease process or to antiparkinson medications.

Primary Symptoms

Bradykinesia is slowness in voluntary movement. It produces difficulty initiating movement as well as difficulty completing movement once it is in progress. The delayed transmission of signals from the brain to the skeletal muscles, due to diminished dopamine, produces bradykinesia.

Tremors in the hands, fingers, forearm, or foot tend to occur when the limb is at rest but not when performing tasks. Tremor may occur in the mouth and chin as well.

Rigidity, or stiff muscles, may produce muscle pain and an expressionless, mask-like face. Rigidity tends to increase during movement.

Poor balance is due to the impairment or loss of the reflexes that adjust posture in order to maintain balance. Falls are common in people with Parkinson's.

Parkinsonian gait is the distinctive unsteady walk associated with

Parkinson's disease. There is a tendency to lean unnaturally backward or forward, and to develop a stooped, head-down, shoulders-drooped stance. Arm swing is diminished or absent and people with Parkinson's tend to take small shuffling steps (called festination). Someone with Parkinson's may have trouble starting to walk, appear to be falling forward as they walk, freeze in mid-stride, and have difficulty making a turn.

Secondary Symptoms
The progressive loss of voluntary and involuntary muscle control produces a number of secondary symptoms associated with Parkinson's. Most patients do not experience all of them, and symptoms vary in intensity from person to person.

Some secondary symptoms of Parkinson's disease include the following:

  • Constipation
  • Difficulty swallowing (dysphagia)–saliva and food that collects in the mouth or back of the throat may cause choking, coughing, or drooling
  • Excessive salivation (hypersalivation)
  • Excessive sweating (hyperhidrosis)
  • Loss of bladder and/or bowel control (incontinence)
  • Loss of intellectual capacity (dementia)–late in the disease
  • Psychosocial: anxiety, depression, isolation
  • Scaling, dry skin on the face and scalp (seborrhea)
  • Slow response to questions (bradyphrenia)
  • Small, cramped handwriting (micrographia)
  • Soft, whispery voice (hypophonia)